منابع مشابه
Thrombomodulin/activated protein C system in septic disseminated intravascular coagulation
The thrombomodulin (TM)/activated protein C (APC) system plays an important role in maintaining the homeostasis of thrombosis and hemostasis and maintaining vascular integrity in vivo. TM expressed on vascular endothelium binds to thrombin, forming a 1:1 complex and acts as an anticoagulant. In addition, the thrombin-TM complex activates protein C to produce APC, which inactivates factors VIIIa...
متن کاملProtein C and thrombomodulin in human acute lung injury.
Decreased circulating protein C and increased circulating thrombomodulin are markers of the prothrombotic, antifibrinolytic state associated with poor outcomes in sepsis but have not been measured in patients with ALI (acute lung injury)/ARDS (acute respiratory distress syndrome). We measured circulating and intra-alveolar protein C and thrombomodulin in 45 patients with ALI/ARDS from septic an...
متن کاملA novel function of the endothelial thrombomodulin-protein C system for cellular function in the CNS
Loss of endothelial thrombomodulin (TM) function is associated with macrovascular, microvascular, and inflammatory diseases. Loss of TM function impairs the generation of the anticoagulant protease activated protein C (aPC), which conveys important neuroprotective effects. Yet, the physiological relevance and the mechanism through which the TM-aPC system maintains nerve function remain unknown....
متن کاملThrombomodulin-protein C-EPCR system: integrated to regulate coagulation and inflammation.
Late in the 18th century, William Hewson recognized that the formation of a clot is characteristic of many febrile, inflammatory diseases (Owen C. A History of Blood Coagulation. Rochester, Minnesota: Mayo Foundation; 2001). Since that time, there has been steady progress in our understanding of coagulation and inflammation, but it is only in the past few decades that the molecular mechanisms l...
متن کاملThe endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex.
Protein C activation on the surface of the endothelium is critical to the negative regulation of blood coagulation. We now demonstrate that monoclonal antibodies that block protein C binding to the endothelial cell protein C receptor (EPCR) reduce protein C activation rates by the thrombin-thrombomodulin complex on endothelium, but that antibodies that bind to EPCR without blocking protein C bi...
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ژورنال
عنوان ژورنال: Blood & Vessel
سال: 1987
ISSN: 0386-9717,1884-2372
DOI: 10.2491/jjsth1970.18.289